Endocrine Abstracts

Bariatric surgery, also known as metabolic surgery, has been shown through multiple clinical trials to result in superior efficacy and sustainability of weight loss and remission of diabetes after surgery in patients with extreme obesity compared with intensive medical and lifestyle interventions. Although the metabolic effects of bariatric surgery have been observed for over 50 years, the primary molecular mechanisms underlying these effects are not well understood. A number ...

It is generally considered that sight-threatening retinopathy is most unlikely within 5 years of diagnosis in a young patient with acute onset diabetes. We present the case of a 27 year old who developed severe bilateral proliferative retinopathy within 6 months of diagnosis.She consulted her about GP about long standing irregular periods. As she was overweight the GP checked a random blood sugar which was16. HBAIC was 9.2%. There was a family history of...

Background: Diagnostic thyroid scans using technetium-99m pertechnetate are widely used to differentiate the causes of hyperthyroidism. Only 1-5% of the administered isotope is taken up by the thyroid after 20 minutes resulting in high background radioactivity.Objectives: To determine the effective radiation dose and calculated organ doses after a standard administration of Technetium-99m pertechnetate</ce:under...

Objectives: To collect qualitative and quantitative information on the burden of adult growth hormone deficiency (AGHD) diagnostic tests for the patient.Methods: A survey was published on The Pituitary Foundation’s website and social media pages; respondents completed it online using SmartSurvey over period of two months (October-November 2021). 105 respondents took the survey, with 9 screened out after the first question because they had never take...

Plasma and urine 18-hydroxycortisol ('18-OHF') measurements are helpful to discriminate primary hyperaldosteronism (Conn's syndrome) caused by adrenal hyperplasia (normal 18-OHF) from adrenal adenoma or glucocorticoid suppressible hyperaldosteronism ( raised 18-OHF). We have developed DELFIA time-resolved fluorescence assays for 18-OHF as a second-line biochemical investigation for patients with raised plasma aldosterone/ renin ratios. Following ether extraction, test samples ...